方亮

教授、博士生导师、药学院院长,世界中医药联合会中药药剂专业委员会常务理事,Asian Journal of Pharmaceutical Sciences 编委,国家食品药品监督管理局新药审评专家,国家自然科学基金函审评议专家

教师职称: 教授,博士生导师 主讲科目:
  • 药剂学

简介

姓名:方亮

性别:

籍贯:吉林

联系电话:02423986330

E-Mail:fangliangsp@yahoo.com.cn

个人主页:

职称/职务:教授/博士生导师/药学院院长

通讯地址:沈阳市沈河区文化路103号

邮政编码:110016

学习/工作经历:

1987年7月, 沈阳药学院药学系药物制剂专业毕业
1987年8月~1988年12月,吉林省医药工业研究所任助理工程师
1989年1月~1992年7月,吉林省延边医药管理局工业科任科员
1992年8月~1994年2月,吉林省延边中药厂任副厂长,工程师
1994年3月~2000年3月,延边大学药学院药剂学教研室任讲师,副教授
1999年7月,在延边大学药学院获得理学硕士学位
1999年4月~2000年3月,以日中笹川医学研究者制度第22期生身份在日本城西大学药学部留学
2003年3月,在日本城西大学药学部获得药学博士学位
2003年4月~2004年3月,日本城西大学药学部博士后
2004 年 4 月~现在,沈阳药科大学药学院药剂教研室任教授
 


兼职情况:

世界中医药联合会中药药剂专业委员会常务理事
Asian Journal of Pharmaceutical Sciences 编委
国家食品药品监督管理局新药审评专家
国家自然科学基金函审评议专家
教育部留学回国人员科研启动基金评审专家
辽宁省委省政府决策咨询委员会中青年专家
重庆市化学制药工程技术中心技术委员会成员
沈阳药科大学学位评定委员会药剂学分科委员会主席
《沈阳药科大学学报》常务编委
 


科研/获奖情况:

近五年来,主持了国家自然科学基金项目“两亲经皮促透剂薄荷醇修饰物酯的结构优化及促透机制的研究”(批准号:81173007)和“l-香芹醇酯类衍生物经皮促透作用的可逆性及其机理研究”(批准号:30973654)两项、高等学校博士学科点专项基金项目“l-香芹醇酯类衍生物经皮促透作用的可逆性及其机理研究”(批准号:20092134110002)一项、国家“十一五重大新药创制”大平台子项目“左旋氨氯地平贴剂的开发”(新药2009ZX09301—012)一项,国家“十一五重大新药创制”辽宁省国家创新药物孵化(本溪)基地建设子项目“阿扎司琼贴剂的开发”(新药2010ZX09401—304)一项,参与国家科技部“973”重大科学研究计划项目“纳米技术改善难溶性药物功效的应用基础研究”(2009CB903302)一项。在国际学术会议上,作大会报告6次,申请专利12项,授权专利2项,2011年被评为沈阳药科大学教学名师。


教学/指导研究生情况:

讲授本科生课程:药剂学、生物药剂学、药物动力学

指导博士研究生16名(其中毕业7名)、硕士研究生30名(其中毕业 18名)


发表论文/出版著作:

发表论文:在国内外学术期刊发表论文70多篇,其中SCI收载30多篇。

编写著作:

《药剂学学习指导书》(主编)中国医药科技出版社,2011年
《经皮给药新剂型》(副主编)人民卫生出版社,2006年
《药用高分子材料学》(副主编)中国医药科技出版社,2009年
 《药物制剂注解》(副主编)人民卫生出版社,2010年
 《药剂学》(第二版)(编者)中国医药科技出版社,2010年
  《药剂学》(第七版)(编者)人民卫生出版社,2011年
  《中华医学百科全书药剂学分卷》(编者),正在编写。
 近期发表的SCI收入论文:
1. HL, Xi, L Fang. The relationship between hydrogen-bonded ion-pair stability and transdermal penetration of lornoxicam with organic amines. Eur J Pharm Sci, accepted. (通讯作者)
2. NX, Zhao, DM Cun, W Li, L Sun, HL Xi, L Li, L Fang. In vitro percutaneous absorption enhancement of granisetron by chemical penetration enhancers. Drug Deve Ind Pharm, accepted. (DOI: 10.3109/03639045.2012.665924) (通讯作者)
3. N Zeng, QY Hu, ZY Liu, XL Gao, RK Hu, QX Song, GZGu, HM Xia, L Yao, ZQ Pang, XG Jiang, J Chen, L Fang. Preparation and characterization of paclitaxel-loaded DSPE-PEG-liquid
crystalline nanoparticles (LCNPs) for improved bioavailability. Int J Pharm, 2012, 424:58-56. (通讯作者)
4. J Liu, ZY Wang, C Liu, HL Xi, CM Li, Y Chen, L Sun, L Mu, L Fang. Silicone adhesive, a better matrix for tolterodine patches—a research based on in vitro/in vivo studies. Drug Deve Ind Pharm, accepted. (DOI: 10.3109/03639045.2011.637049) (通讯作者)
5. ZY Wen; ZQ Yan; K Hu; R He; ZQ Pang; LR Guo; Y Qian; XG Jiang; L Fang. Brain targeting and toxicity study of odorranalectin-conjugated nanoparticles following intranasal administration. Drug Delivery, 2011, 18 (3): 555-561. (通讯作者)
6.W Sun, W Tian, Y Zhang, J He, S Mao, L Fang. Effect of novel stabilizers—cationic polymers on the particle size and physical stability of poorly soluble drug nanocrystals. Nanoedicine, accepted. (通讯作者)
7. CM Li, C Liu, J Liu, L Fang. Correlation Between Rheological Properties, In Vitro Release, and Percutaneous Permeation of Tetrahydropalmatine. AAPS Pharm Sci Tech, 2011, 12 (3): 1002-1010. (通讯作者)
8. W Sun, SR Mao, Y Shi, LC Li, L Fang. Nanonization of itraconazole by high pressure homogenization: Stabilizer optimization and effect of particle size on oral absorption. J Pharm Sci, 2011, 100(8):3365-3373. 
9.ZY Wen; ZQ Yan; K Hu; ZQ Pang; XF Cheng; LR Guo; QZ Zhang; R Lai; XG Jiang; L Fang. Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on parkinson‘s disease following intranasal administration. J Control Release, 2011, (15):131-138. (通讯作者)
10. W Li, YG Yang, YS Tian, XL Xu, YChen, L Mu, YQ Zhang, L Fang. Preparation and in vitro/in vivo evaluation of revaprazan hydrochloride nanosuspension. Int J Pharm, 2011, 408:157-162. (通讯作者)
11.LG Zhao, L Fang, YN Xu, N Zheng, ZG He. Effect of (E)-2-isopropyl-5- methylcyclohexyl octadec-9-enoate on transdermal delivery of aconitum alkaloids. Drug Deve Ind Pharm, 2011;37(3):290-299. (通讯作者)
12.L Li, L Fang, XL Xu, Y Liu, YH Sun, ZG He. The Transdermal Patches for Site-Specific Delivery of Letrozole: A New Option for Breast Cancer Therapy. AAPS Pharm Sci Tech, 2010, 11(3):1054-7. (通讯作者)
13.X Ma, L Fang, JP Guo, NX Zhao, ZG He. Effect of counter-ions and penetration enhancers on the skin permeation of flurbiprofen. J Pharm Sci, 2010, 99(4):1826-1837. (通讯作者)
14.HL Xi, YG Yang, DM Zhao, L Fang, L Sun, LW Mu, J Liu, NX Zhao, YY Zhao, N Zheng, ZG He. Transdermal patches for site-specific delivery of anastrozole: In vitro and local tissue disposition evaluation. Int J Pharm, 2010, 391:73–78. (通讯作者)
15.L Li, L Fang, XL Xu, Y Liu, YH Sun, ZG He. Formulation and biopharmaceutical evaluation of a transdermal patch containing letrozole. Biopharmaceutics & Drug Disposition, 2010, 31: 138-149. (通讯作者)
16. Y Liu, SD Yoo, L Fang, X Jin, L Li, TF Li. . Ion-pair LC-UV method for the determination of boanmycin in moude plasma and its application to a pharmacokinetic atudy. Chromatographia, 2010, 72:357-359.
17. YH Suna, L Fang, M Zhua, W Li , P Meng, L Li, ZG He. A drug-in-adhesive transdermal patch for S-amlodipine free base: In vitro and in vivo characterization. Int J Pharm, 2009, 382 : 165–171 (通讯作者)
18.Z Tan, JY Zhang, J Wu, L Fang, ZG He. The Enhancing Effect of Ionpairing on the Skin Permeation of Glipizide. AAPS Pharm Sci Tech, 2009, 10(3):967-976. (通讯作者) 
19.Y Liu, SD Yoo, L Fang, X Jin, L Li, YJ Ren, CS Yao, TF Li. Determiniation of boanmycinin pharmaceiytical preparations by a simple and rapid ion-pair LC method. Chromatographia, 2009, 70:643-646.
20.LG Zhao, Y Li, L Fang, YN Xu, ZG He. Transdermal delivery of tolterodine by O-acylmenthol: In vitro/in vivo correlation. Int J Pharm, 2009, 374: 73–81. (通讯作者)
21.LG Zhao, Y Li, L Fang, YN Xu, ZG He. Effect of O-acylmenthol and salt formation on the skin permeation of diclofenac acid. Drug Dev Ind Pharm, 2009, 35: 814–826 (通讯作者) 
22.ZY Wen, L Fang, ZG He. Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro. Drug Delivery, 2009, 16: 214-223. (通讯作者)
23.JY Zhang, L Fang, Zhe Tan, Jian Wu, and Zhong-Gui He. Influence of ion-pairing and chemical enhancers on the transdermal delivery of meloxicam. Drug Dev Ind Pharm, 2009; 35: 663–670. (通讯作者)
24.CS Ren, L Fang, L Ling, Q Wang, S Liu, LG Zhao, ZG He. Design and in vivo evaluation of an indapamide transdermal patch. Int J Pharm, 2009, 370: 129-135. (通讯作者)
25.LG Zhao, L Fang, YN Xu, S Liu, ZG He, YY Zhao. Transdermal delivery of penetrants with differing lipophilicities using O-acylmenthol derivatives as penetration enhancers. Eur J Pharm Biopharm, 2008, 69:199–213. (通讯作者)
26.LG Zhao, L Fang, YN Xu, YY Zhao, ZG He. Effect of O-acylmenthol on transdermal delivery of drugs with different lipophilicity. Int J Pharm, 2008, 352: 92–103. (通讯作者)
27.CS Ren, L Fang, T Li, ML Wang, LG Zhao, ZG He. Effect of permeation enhancers and organic acids on the skin permeation of indapamide. Int J Pharm, 2008, 350: 43–47. (通讯作者)
28.ML Wang, L Fang, CS Ren, T Li. Effect of ion-pairing and enhancers on scutellarin skin permeability. J Pharm Pharmacol, 2008, 60: 425–435. (通讯作者)
29. YX Jiang, L Fang, XC Niu, R Ma, ZG He. The effect of ion pairing on the skin permeation of amlodipine. Die pharmazie, 2008, 63(5): 356-360. (通讯作者)
30.R Ma, L Fang, XC Niu, YX Jiang, ZG He. Effect of ion-pairing on the permeation of glibenclamide through rat skin. J Drug Deliv Sci Tech, 2008, 18(4): 279-284. (通讯作者)
31.Y Morimoto, M Mutoh, H Ueda, L Fang, K Hirayama, M Atobe, D Kobayashi. Elucidation of the transport pathway enhanced by low-frequency sonophoresis using hydrodynamic pore theory and confocal microscopy in hairless rat skin. J Control Release, 2005, 103: 587–597.
32. L Fang, S Numajiri, D Kobayashi, H Ueda, K Nakayama, H Miyamae, Y Morimoto. Physicochemical and crystallographic characterization of mefenamic acid complexes with alkanolamines. J Pharm Sci, 2004, 93: 144–54.
33. L Fang, S Numajiri, D Kobayashi, Y Morimoto. The use of complexation with alkanolamines to facilitate skin permeation of mefenamic acid. Int J Pharm, 2003, 262: 13–22.
34. L Fang, Y Kobayashi, S Numajiri, D Kobayashi, Y Morimoto. The enhancing effect of a triethanolamine- ethanol-isoproply myristate mixed system on the skin permeation of acidic drugs. Biol Pharm Bull, 2002, 25: 1339–1344.
35. S Ohmori, L Fang, M Kawase, S Saito, Y Morimoto. Tolerance to analgesia and dependence liability by topical application of dihydroetorphine to hairless rats. Eur J Pharmacol, 2001, 423: 157–166.

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